The Center for BrainHealth, part of The University of Texas at Dallas' school of Behavioral and Brain Sciences, is a research institute focused exclusively on brain health that combines brain research with clinical interventions. Founded by Dr. Sandra Bond Chapman in 1999,[1] the Center for BrainHealth houses 125 researchers, postdoctoral research fellows, doctoral students, master’s students, and research clinicians who work on 60 privately and federally funded research projects. The Center provides academic training and houses specialists in, among many others, Alzheimer’s disease, traumatic brain injury (TBI), healthy brain aging, autism, Attention Deficit Hyperactivity Disorder (ADHD), stroke, and Post-Traumatic Stress Disorder (PTSD). To help raise awareness of and funding for important leading-edge scientific research underway at the Center for BrainHealth, a number of proponent groups have formed. These include the Think Ahead Group (TAG), young professionals vitally interested in the cause of brain health, and Friends of BrainHealth, an organization of passionate citizens who work to promote enhanced brain health fitness awareness.[2]
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Researchers work side-by-side with clinicians, which is unique at the Center for BrainHealth compared to other centers. Brain scientists at the Center use diverse, state-of-the-art technologies to elucidate how brain networks can be strengthened and reconnected, including electroencephalography (EEG) to record the brain’s electrical rhythms during cognitive task performance, functional MRI (fMRI) scans to measure brain blood flow during cognitive tasks, an indicator of brain activity and brain morphometrics to measure size and shape differences of brain regions to millimeter accuracy.[3] The Center houses leading experts in various fields of neuroscience, and has produced an array of publications from members of the BrainHealth Team.[4] Research initiatives include:
| Healthy Brain | •Provide BrainHealth Fitness Checkups, cognitive-linguistic assessments to establish baseline function, highlight strengths, identify weaknesses, and provide recommendations to preserve mental abilities
•Expand the knowledge of Brainomics, the improvement of corporate environments by increasing workforce mental productivity. Brainomics addresses the unique modern business phenomenon of having four generations (Traditionalist, Boomer, Gen X, and Millennial) work together side-by-side in the same environment. Brainomics, a term coined by Dr. Sandra Bond Chapman, looks for ways to strengthen the brain's important frontal lobes, take advantage of dramatic brain plasticity as people age, and challenge mental talents and capacities. |
| Semantic Memory Processing in Normal Adults | •Establish localization of brain regions associated with different sub-types of memory |
| Brain Training | •Evaluate the effect of novel brain training in normally aging adults |
| Traumatic Brain Injury/Stroke | •Cognitive and social outcome of pediatric TBI: Investigating impact of impairments on academic, social, and psychological functioning •Memory deficits following pediatric TBI: Evaluating changes in working memory and related brain activation in those with head injury •Brain imaging and genetics in Social Cognition: establishing battery to assess social cognition •Genetic factors and outcome from TBI: examining a pre-disposition to recovery potential after brain injury •Growth and abnormalities after pediatric TBI: developing procedures for medical testing and treatment •Self regulation abilities in children with severe TBI: development of self regulation evaluation tools for children with severe brain injury and the subsequent foundation for rehabilitation •Cognitive retraining and memory dysfunction in brain injury of adults: neuroimaging biomarkers and diagnostic tools for working memory and semantic memory deficits in head injury and cognitive rehabilitation treatment paradigm |
| Gulf War syndrome | •Development of diagnostic criteria for Gulf War Syndrome |
| Attention Deficit Hyperactivity Disorder | •Development and implementation of SMART intervention program |
| Autism/Asperger Syndrome | •Establish assessment battery for social cognition •Development of various intervention programs using virtual computer technology |
| Dementia | •Language of Hereditary Dysphasic Disinhibition Dementia: examination of linguistic markers of early disease onset •Discourse Assessment of Frontotemporal Lobar Degeneration (FTLD):analysis of language to differentiate differences between subtypes of FTLD, Alzheimer's, and healthy controls •Semantic Memory and Gist Performance in Frontotemporal Lobar Degeneration, Mild Cognitive Impairment, and Alzheimer's using fMRI and EEG: characterizing language distinctions in populations |
The Center for BrainHealth, part of The University of Texas at Dallas (UTD), was established in 1999 under the direction of Dr. Sandra Bond Chapman, UT Dallas' Dee Wyly Distinguished Chair in Brain Health.[5] Originally located at UT Dallas' Callier Center for Communication Disorders, in 2004 the Texas Higher Education Coordinating Board approved the purchase and renovation of a nearby building at 2200 Mockingbird Lane in Dallas to be the Center's own facility. This facility is adjacent to the UT Southwestern North Campus. The Center’s virtual lab is part of the National Pediatric Acquired Brain Injury Plan, and in 2004 the BrainHope Program was established for children with traumatic brain injuries. Also in 2004, Dee and Charles Wyly endowed the $2-million Dee Wyly Distinguished Chair at the Center and a $1.5-million gift from Sallie and Frederic B. Asche, Jr., to enable the establishment of the Sallie and Frederic B. Asche Jr. Advanced Treatment Wing at the Center for BrainHealth.[6][7] In 2005 the Center received a $2-million gift to endow a chair for the Center’s medical science director.[8] The Center’s memory research initiatives were expanded in 2006 with $1 million to establish the Berman Laboratory for Learning and Memory and the Berman Scholars Program for young researchers doing postdoctoral training in memory.[9] In 2007, businessman and philanthropist T. Boone Pickens donated $5 million to the Center for BrainHealth to fund educational and research initiatives in the area of brain science.[10] In 2008, the Center’s Middle School Brain Years project conducted the pilot study of its Strategic Memory and Reasoning Training (SMART) Program, an experimental curriculum designed to improve strategic reasoning skills in teens. The pilot study's success led to a $6 million grant from Texas Legislature for the project's expansion.[11]
The Center for BrainHealth is located in a 63,000-square-foot (5,900 m2) building designed by Kyley Harvey of HKS, Inc., on a 3.5 acres (0.014 km2) site near the UT Dallas' Callier Center for Communication Disorders and the University of Texas Southwestern Medical Center in the city of Dallas. In 2004, UT Dallas purchased a building with a $5 million donation from Dianne Cash. The new building was named the Frances and Mildred Goad Building in honor of Cash's mother and grandmother, both of whom had benefited from the Center's efforts.[12] Originally constructed in 1970, the redesign and remodel was an extensive undertaking that began in June 2005, completed in September 2006, with the building formally dedicated on January 26, 2007.[13][14] Each floor of the facility is dedicated to carrying out a significant aspect of BrainHealth’s mission and includes a state-of-the-art auditorium, virtual classrooms, the T. Boone Pickens Virtual Learning Center, and a reception hall. The second floor contains high-powered computers and data analysis tools, as well as an outlet for brain scientists, engineers, and technology experts to explore data. The third floor houses clinically based research projects, including a facility for individuals to undergo brain fitness checkups for discovering ways to prevent memory decline and a place for adults and children to participate in research aimed at learning more about how to strengthen brain function after injury or disease. The Center for BrainHealth houses electroencephalography labs, data analysis tools, MRI machines, an rTMS (Repetitive Transcanial Memory Stipulation) lab, and brain morphometric laboratories.[15]
Think Ahead Group (TAG) is a young professionals group based in Dallas, Texas, that raises awareness of brain health and funds for research taking place at the Center for BrainHealth.
The Think Ahead Group was founded in October 2009 by a small group of individual and now includes over 300 members. All contributions support the cause of brain health and the Center’s many research focus areas-Alzheimer’s disease, traumatic brain injury (TBI), autism, Attention Deficit Hyperactivity Disorder (ADHD), stroke, Post-Traumatic Stress Disorder (PTSD), Addiction , BrainHealth Physical, Dementia, Exercise and the Brain, Healthy Brain Aging, and Virtual Brain Training.
In 2010, the Think Ahead Group raised $25,000 in support of the research study “Neuroscience to Neuro-rehabilitation.” [16] The Center’s Molly Keebler and Asha Vas had their work with Traumatic Brain Injury patients recognized by TAG and won the TAG Research Award based on its proven potential to help brain injury survivors lead better, more independent lives. The inaugural $25,000 award, selected in a blind ballot voted on by members of TAG’s Board of Directors, was selected from two dozen research proposals. Traumatic brain injury resulting from a car crash, fall, sports concussion, or similar head shock can turn normal life upside down. Recent behavioral and image and research has shown that, in order to maximize brain function TBI treatment strategies need to be directed to higher-order critical thinking skills mediated by the brains frontal lobe. The Strategic Memory and Reasoning Training (SMART©),[17] a treatment program created by the Center for BrainHealth to address such higher-order abilities as strategic attention and complex reasoning, offers fresh hope for TBI.
The TAG Advisory Board [18] is composed of 19 young professionals in Dallas who meet monthly to discuss opportunities to raise funds for the Center, gain new members, and promote brain health awareness and research. The current TAG board members are: Bradley Agather, Court Alley, Julie Carter, Secretary, Justin Cox, Maggie Flagg, Treasurer, Stephanie Fox, Hadleigh Henderson, Amie Mayes, Ginna McLanahan, Sarah Monning, Vice President, Sam Owen, Steve Owen, Beth Peters, Nick Peters, President, Abby Ruth, Peter Ruth, Ellen Schlachter, Molly Soper, Andrew Tuttle.